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Molecular Basis of Heredity: Part 3. Genetic Variation

Author(s): Raye L. Alford, PhD

The Molecular Basis of Heredity Part III: The Molecular Basis of Genetic Variation

In this slide set we will explore the molecular basis of genetic variation, including mechanisms and types of DNA sequence variations, the importance of DNA sequence variations, and the patterns of inheritance of genetic disorders.

The image on this slide is a photograph of the model of the DNA molecule built by Drs. James Watson and Francis Crick in 1953. Drs. Watson and Crick used this model to depict their proposed structure for the DNA double helix. The hypothesized structure was derived from X-ray diffraction data produced by Drs. Maurice Wilkins and Rosalind Franklin. The model was constructed from metal scraps obtained from a machine shop.

Drs. Watson and Crick published their proposed DNA structure in the journal Nature on April 2, 1953 (Volume 171, page 737). For their work, Drs. Watson, Crick and Wilkins were awarded the Nobel Prize in Physiology or Medicine in 1962. Dr. Franklin died before 1962. Since Nobel Prizes are awarded only to living individuals, she could not be honored.