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New Hope for Fading Memories: Alzheimer's Disease

Author(s): Ronald McNeel DrPH

Formation of Tangles in Neurons

In the case of tangles, microtubules form an support structure inside the neurons. The protein, tau, acts like a sort of scaffolding network to keep these microtubules stable. In Alzheimer's Disease (AD), changes occur that cause the support threads of tau to become tangled. Eventually, the neuron support structure collapses. This results in decreased communication and transport between neurons and ultimately, the death of the neurons.